2025 01 v.59 1-12
转录因子acj6在昆虫嗅觉中的功能研究进展
基金项目(Foundation):
国家自然科学基金项目（32370525）;
河南省自然科学基金项目（232300420012）;
河南省大学生创新创业训练计划项目（202210466060）
邮箱(Email):
xincheng@henau.edu.cn;
DOI:
10.16445/j.cnki.1000-2340.20241121.001
中文作者单位:
河南农业大学植物保护学院/河南省害虫绿色防控国际联合实验室;
摘要(Abstract):
综述了acj6的发现及突变造成的嗅觉异常行为，介绍了acj6的结构及表达模式，阐述了acj6在昆虫嗅觉中的功能，包括调控Or表达、塑造嗅觉神经元的形态和靶向、维持神经递质乙酰胆碱水平和调控嗅小球形成，指出今后应注重研究acj6对昆虫嗅觉的调控机制、与其他转录因子的互作关系，以期为阐明昆虫的嗅觉调控机制并制定基于嗅觉的害虫防治策略提供参考。
关键词(KeyWords):
acj6;转录因子;嗅觉;嗅觉受体;神经元
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参考文献
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[30] BAI L, CARLSON J R. Distinct functions of acj6 splice forms in odor receptor gene choice[J]. The Journal of Neuroscience, 2010, 30(14):5028-5036.
[31] KOMIYAMA T, CARLSON J R, LUO L Q. Olfactory receptor neuron axon targeting:intrinsic transcriptional control and hierarchical interactions[J]. Nature Neuroscience, 2004, 7(8):819-825.
[32] KOMIYAMA T, JOHNSON W A, LUO L Q, et al.From lineage to wiring specificity POU domain transcription factors control precise connections of Drosophila olfactory projection neurons[J]. Cell, 2003, 112(2):157-167.
[33] ELMORE T, IGNELL R, CARLSON J R, et al. Targeted mutation of a Drosophila odor receptor defines receptor requirement in a novel class of sensillum[J]. The Journal of Neuroscience, 2003, 23(30):9906-9912.
[34] VOSSHALL L B, AMREIN H, MOROZOV P S, et al.A spatial map of olfactory receptor expression in the Drosophila antenna[J]. Cell, 1999, 96(5):725-736.
[35] BAI L, GOLDMAN A L, CARLSON J R. Positive and negative regulation of odor receptor gene choice in Drosophila by acj6[J]. The Journal of Neuroscience, 2009,29(41):12940-12947.
[36] LI H J, LI T C, HORNS F, et al. Single-cell transcriptomes reveal diverse regulatory strategies for olfactory receptor expression and axon targeting[J]. Current Biology, 2020, 30(7):1189-1198.
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[39] TICHY A L, RAY A, CARLSON J R. A new Drosophila POU gene, pdm3, acts in odor receptor expression and axon targeting of olfactory neurons[J]. The Journal of Neuroscience, 2008, 28(28):7121-7129.
[40] WARR C, CLYNE P, DE BRUYNE M, et al. Olfaction in Drosophila:coding, genetics and e-genetics[J].Chemical Senses, 2001, 26(2):201-206.
[41] SAKURAI T, NAKAGAWA T, MITSUNO H, et al.Identification and functional characterization of a sex pheromone receptor in the silkmoth Bombyx mori[J].Proceedings of the National Academy of Sciences of the United States of America, 2004, 101(47):16653-16658.
[42] LI H J, LI T C, HORNS F, et al. Coordinating receptor expression and wiring specificity in olfactory receptor neurons[J]. BioRxiv, 2019(31):594895.
[43] KOMIYAMA T, LUO L Q. Intrinsic control of precise dendritic targeting by an ensemble of transcription factors[J]. Current Biology, 2007, 17(3):278-285.
[44] XIE Q J, LI J F, LI H J, et al. Transcription factor acj6controls dendrite targeting via a combinatorial cellsurface code[J]. Neuron, 2022, 110(14):2299-2314.
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[50] JAFARI S, ALENIUS M. Cis-regulatory mechanisms for robust olfactory sensory neuron class-restricted odorant receptor gene expression in Drosophila[J]. PLoS Genetics, 2015, 11(3):e1005051.
[51] MILLER C J, CARLSON J R. Regulation of odor receptor genes in trichoid sensilla of the Drosophila antenna[J]. Genetics, 2010, 186(1):79-95.
[52] RAY A, VAN D G V N W, SHIRAIWA T, et al.Mechanisms of odor receptor gene choice in Drosophila[J]. Neuron, 2007, 53(3):353-369.
[53] XIE Q J, BRBIC M, HORNS F, et al. Temporal evolution of single-cell transcriptomes of Drosophila olfactory projection neurons[J]. eLife, 2021, 10:e63450.
[54] YAN H, JAFARI S, PASK G, et al. Evolution, developmental expression and function of odorant receptors in insects[J]. The Journal of Experimental Biology,2020, 223(Pt Suppl 1):208215.
[55] CHAI P C, CRUCHET S, WIGGER L, et al. Sensory neuron lineage mapping and manipulation in the Drosophila olfactory system[J]. Nature Communications,2019, 10(1):643.
[2] SHANBHAG S R, MüLLER B, STEINBRECHT R A.Atlas of olfactory organs of Drosophila melanogaster 1.Types, external organization, innervation and distribution of olfactory sensilla[J]. International Journal of Insect Morphology and Embryology, 1999, 28(4):377-397.
[3] DE BRUYNE M, FOSTER K, CARLSON J R. Odor coding in the Drosophila antenna[J]. Neuron, 2001, 30(2):537-552.
[4] DE BRUYNE M, CLYNE P J, CARLSON J R. Odor coding in a model olfactory organ:the Drosophila maxillary palp[J]. The Journal of Neuroscience, 1999, 19(11):4520-4532.
[5] SCHLEGEL P, BATES A S, STüRNER T, et al. Information flow, cell types and stereotypy in a full olfactory connectome[J]. ELife, 2021, 10:e66018.
[6] HANSSON B S, LJUNGBERG H, HALLBERG E, et al. Functional specialization of olfactory glomeruli in a moth[J]. Science, 1992, 256(5061):1313-1315.
[7]赵新成，翟卿，王桂荣.昆虫触角叶的结构[J].昆虫学报，2015, 58(2):190-209.ZHAO X C, ZHAI Q, WANG G R. The structure of the antennal lobe in insects[J]. Acta Entomologica Sinica,2015, 58(2):190-209.
[8]程李莉，康乐，郭晓娇.昆虫嗅觉系统编码规律[J].自然杂志，2023, 45(4):239-246.CHENG L L, KANG L, GUO X J. Principles of insect olfactory system coding[J]. Chinese Journal of Nature,2023, 45(4):239-246.
[9]刘伟，王桂荣.昆虫嗅觉中枢系统对外周信号的整合编码研究进展[J].昆虫学报，2020, 63(12):1536-1545.LIU W, WANG G R. Research progress of integrated coding of peripheral olfactory signals in the central nervous system of insects[J]. Acta Entomologica Sinica,2020, 63(12):1536-1545.
[10] LI Q Y, BARISH S, OKUWA S, et al. A functionally conserved gene regulatory network module governing olfactory neuron diversity[J]. PLoS Genetics, 2016, 12(1):e1005780.
[11] ENDO K, AOKI T, YODA Y, et al. Notch signal organizes the Drosophila olfactory circuitry by diversifying the sensory neuronal lineages[J]. Nature Neuroscience,2007, 10(2):153-160.
[12] MIKA K, BENTON R. Olfactory receptor gene regulation in insects:multiple mechanisms for singular expression[J]. Frontiers in Neuroscience, 2021, 15:738088.
[13] BARISH S, VOLKAN P C. Mechanisms of olfactory receptor neuron specification in Drosophila[J]. Wiley Interdisciplinary Reviews Developmental Biology, 2015,4(6):609-621.
[14] ESTACIO-GóMEZ A, HASSAN A, WALMSLEY E,et al. Dynamic neurotransmitter specific transcription factor expression profiles during Drosophila development[J]. Biology Open, 2020, 9(5):bio052928.
[15] JAFARI S, ALKHORI L, SCHLEIFFER A, et al. Combinatorial activation and repression by seven transcription factors specify Drosophila odorant receptor expression[J]. PLoS Biology, 2012, 10(3):e1001280.
[16] JAN Y N, JAN L Y. Branching out:mechanisms of dendritic arborization[J]. Nature Reviews Neuroscience,2010, 11(5):316-328.
[17] LATCHMAN D S. POU family transcription factors in the nervous system[J]. Journal of Cellular Physiology,1999, 179(2):126-133.
[18]张力，贾弘. POU蛋白调节中枢神经系统发育[J].生物化学与生物物理进展，1994, 21(5):400-403.ZHANG L, JIA H. POU protein regulates the development of central nervous system[J]. Progress in Biochemistry and Biophysics, 1994, 21(5):400-403.
[19] MCKENNA M, MONTE P, HELFAND S L, et al. A simple chemosensory response in Drosophila and the isolation of acj mutants in which it is affected[J]. Proceedings of the National Academy of Sciences of the United States of America, 1989, 86(20):8118-8122.
[20] AYER R K Jr, CARLSON J. acj6:a gene affecting olfactory physiology and behavior in Drosophila[J]. Proceedings of the National Academy of Sciences of the United States of America, 1991, 88(12):5467-5471.
[21] AYER R K Jr, CARLSON J. Olfactory physiology in the Drosophila antenna and maxillary palp:acj6 distinguishes two classes of odorant pathways[J]. Journal of Neurobiology, 1992, 23(8):965-982.
[22] CLYNE P J, CERTEL S J, DE BRUYNE M, et al. The odor specificities of a subset of olfactory receptor neurons are governed by acj6, a POU-domain transcription factor[J]. Neuron, 1999, 22(2):339-347.
[23] FUJII T, KUWAZAKI S, YAMAMOTO K, et al. Identification and molecular characterization of a sex chromosome rearrangement causing a soft and pliable(spli)larval body phenotype in the silkworm, Bombyx mori[J]. Genome, 2010, 53(1):45-54.
[24] FUJII T, FUJII T, NAMIKI S, et al. Sex-linked transcription factor involved in a shift of sex-pheromone preference in the silkmoth Bombyx mori[J]. Proceedings of the National Academy of Sciences, 2011, 108(44):18038-18043.
[25] CERTEL S J, CLYNE P J, CARLSON J R, et al. Regulation of central neuron synaptic targeting by the Drosophila POU protein, acj6[J]. Development, 2000,127(11):2395-2405.
[26] TREACY M N, HE X, ROSENFELD M G. I-POU a POU-domain protein that inhibits neuron-specific gene activation[J]. Nature, 1991, 350(6319):577-584.
[27] GERRERO M R, MCEVILLY R J, TURNER E, et al.Brn-3. 0:a POU-domain protein expressed in the sensory, immune, and endocrine systems that functions on elements distinct from known octamer motifs[J]. Proceedings of the National Academy of Sciences, 1993, 90(22):10841-10845.
[28] XIANG M, ZHOU L, MACKE J P, et al. The brn-3family of POU-domain factors:primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons[J]. The Journal of Neuroscience, 1995, 15(7 Pt 1):4762-4785.
[29]臧中旭.棉铃虫转录因子acj6鉴定及其在雄蛾嗅觉发育中的功能初探[D].郑州：河南农业大学，2022.ZANG Z X. Identification of Helicoverpa armigera transcription factor acj6 and its function in the olfactory development of male moths[D]. Zhengzhou:Henan Agricultural University, 2022.
[30] BAI L, CARLSON J R. Distinct functions of acj6 splice forms in odor receptor gene choice[J]. The Journal of Neuroscience, 2010, 30(14):5028-5036.
[31] KOMIYAMA T, CARLSON J R, LUO L Q. Olfactory receptor neuron axon targeting:intrinsic transcriptional control and hierarchical interactions[J]. Nature Neuroscience, 2004, 7(8):819-825.
[32] KOMIYAMA T, JOHNSON W A, LUO L Q, et al.From lineage to wiring specificity POU domain transcription factors control precise connections of Drosophila olfactory projection neurons[J]. Cell, 2003, 112(2):157-167.
[33] ELMORE T, IGNELL R, CARLSON J R, et al. Targeted mutation of a Drosophila odor receptor defines receptor requirement in a novel class of sensillum[J]. The Journal of Neuroscience, 2003, 23(30):9906-9912.
[34] VOSSHALL L B, AMREIN H, MOROZOV P S, et al.A spatial map of olfactory receptor expression in the Drosophila antenna[J]. Cell, 1999, 96(5):725-736.
[35] BAI L, GOLDMAN A L, CARLSON J R. Positive and negative regulation of odor receptor gene choice in Drosophila by acj6[J]. The Journal of Neuroscience, 2009,29(41):12940-12947.
[36] LI H J, LI T C, HORNS F, et al. Single-cell transcriptomes reveal diverse regulatory strategies for olfactory receptor expression and axon targeting[J]. Current Biology, 2020, 30(7):1189-1198.
[37] KREHER S A, KWON J Y, CARLSON J R. The molecular basis of odor coding in the Drosophila larva[J]. Neuron, 2005, 46(3):445-456.
[38] KREHER S A, MATHEW D, KIM J, et al. Translation of sensory input into behavioral output via an olfactory system[J]. Neuron, 2008, 59(1):110-124.
[39] TICHY A L, RAY A, CARLSON J R. A new Drosophila POU gene, pdm3, acts in odor receptor expression and axon targeting of olfactory neurons[J]. The Journal of Neuroscience, 2008, 28(28):7121-7129.
[40] WARR C, CLYNE P, DE BRUYNE M, et al. Olfaction in Drosophila:coding, genetics and e-genetics[J].Chemical Senses, 2001, 26(2):201-206.
[41] SAKURAI T, NAKAGAWA T, MITSUNO H, et al.Identification and functional characterization of a sex pheromone receptor in the silkmoth Bombyx mori[J].Proceedings of the National Academy of Sciences of the United States of America, 2004, 101(47):16653-16658.
[42] LI H J, LI T C, HORNS F, et al. Coordinating receptor expression and wiring specificity in olfactory receptor neurons[J]. BioRxiv, 2019(31):594895.
[43] KOMIYAMA T, LUO L Q. Intrinsic control of precise dendritic targeting by an ensemble of transcription factors[J]. Current Biology, 2007, 17(3):278-285.
[44] XIE Q J, LI J F, LI H J, et al. Transcription factor acj6controls dendrite targeting via a combinatorial cellsurface code[J]. Neuron, 2022, 110(14):2299-2314.
[45] LI H J, HORNS F, WU B, et al. Classifying Drosophila olfactory projection neuron subtypes by singlecell RNA sequencing[J]. Cell, 2017, 171(5):1206-1220.
[46] NAMIKI S, FUJII T, SHIMADA T, et al. The morphology of antennal lobe projection neurons is controlled by a POU-domain transcription factor Bmacj6 in the silkmoth Bombyx mori[J]. Scientific Reports, 2017, 7(1):14050.
[47] LEE M H, SALVATERRA P M. Abnormal chemosensory jump 6 is a positive transcriptional regulator of the cholinergic gene locus in Drosophila olfactory neurons[J]. The Journal of Neuroscience, 2002, 22(13):5291-5299.
[48] GUPTA A P. Arthropod brain:its evolution, development, structure, and functions[M]. New York:Wiley,1987.
[49]陈淑婷.雄性棉铃虫acj6突变体触角叶的结构组织和三维重建析[D].郑州：河南农业大学，2024.CHEN S T. Structural organization and threedimensional reconstruction of antennal lobes in acj6mutant of male Helicoverpa armigera[D]. Zhengzhou:Henan Agricultural University, 2024.
[50] JAFARI S, ALENIUS M. Cis-regulatory mechanisms for robust olfactory sensory neuron class-restricted odorant receptor gene expression in Drosophila[J]. PLoS Genetics, 2015, 11(3):e1005051.
[51] MILLER C J, CARLSON J R. Regulation of odor receptor genes in trichoid sensilla of the Drosophila antenna[J]. Genetics, 2010, 186(1):79-95.
[52] RAY A, VAN D G V N W, SHIRAIWA T, et al.Mechanisms of odor receptor gene choice in Drosophila[J]. Neuron, 2007, 53(3):353-369.
[53] XIE Q J, BRBIC M, HORNS F, et al. Temporal evolution of single-cell transcriptomes of Drosophila olfactory projection neurons[J]. eLife, 2021, 10:e63450.
[54] YAN H, JAFARI S, PASK G, et al. Evolution, developmental expression and function of odorant receptors in insects[J]. The Journal of Experimental Biology,2020, 223(Pt Suppl 1):208215.
[55] CHAI P C, CRUCHET S, WIGGER L, et al. Sensory neuron lineage mapping and manipulation in the Drosophila olfactory system[J]. Nature Communications,2019, 10(1):643.
基本信息:
DOI：10.16445/j.cnki.1000-2340.20241121.001
中图分类号:S433
引用信息:
[1]谢桂英,张继康,陈淑婷等.转录因子acj6在昆虫嗅觉中的功能研究进展[J].河南农业大学学报,2025,59(01):1-12.DOI:10.16445/j.cnki.1000-2340.20241121.001.
基金信息:
国家自然科学基金项目（32370525）; 河南省自然科学基金项目（232300420012）; 河南省大学生创新创业训练计划项目（202210466060）