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阐述了猪链球菌（Streptococcus suis,SS）中常见毒力调节因子的种类和概念，重点综述了二元信号转导系统、转录因子、密度感应系统、RNA结合蛋白、sRNA 5种调节因子对猪链球菌毒力的调控及其相关作用机制。目前在猪链球菌毒力调节因子的研究中缺乏对细菌毒力综合调控网络和分子作用机制的深刻分析，下一步应利用先进的生物技术多维度解析毒力调节因子的分子调控网络与机制，为进一步深入了解猪链球菌的致病机制、开发更有效的防控策略提供理论依据。
Abstract：This article elucidates the types and concepts of common virulence regulators in Streptococcus suis(SS), and focuses on reviewing the regulation of virulence and related mechanisms of five regulatory factors, including two-component signal transduction system, transcription factor, quorum sensing system, RNA-binding protein, and sRNA. Currently, there is a lack of in-depth analysis of the comprehensive regulatory network and molecular mechanisms in the research of virulence regulatory factors of Streptococcus suis. In the future, advanced biotechnological approaches could be used to analyze the molecular regulatory network and mechanism of virulence regulators to enhance our understanding of the pathogenic mechanisms of Streptococcus suis and improve prevention and control strategies.
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基本信息:
DOI：10.16445/j.cnki.1000-2340.20250205.003
中图分类号:S852.611
引用信息:
[1]冯于童,胡金旺,董芳婷等.猪链球菌中常见的毒力调节因子研究进展[J].河南农业大学学报,2025,59(04):580-591.DOI:10.16445/j.cnki.1000-2340.20250205.003.
基金信息:
国家自然科学基金项目(32102673); 中国博士后科学基金面上项目(2020M682297)